Wednesday, January 23, 2013
Researchers have shown that grape seed extract is effective in inhibiting the growth of colorectal cancer cells while having no negative effect on healthy cells. Further, they found that the more advanced the cancer, the smaller the dose of grape seed extract required to deliver the same cancer-killing effect and the more effectively the extract stops cancer-cell growth and survival. (Scientists have known for a while that bioactive compounds in grape seed extract selectively target many types of cancer cells, but the mechanism has been unknown.)
It required less than half the concentration of grape seed to kill 50 percent of more serious stage IV cells than it did to achieve similar results in the less serious stage II cells. But when antioxidants were introduced, the previously induced death, or apoptosis, of cancer cells by grape seed was reversed. This suggests that grape seed kills cancer cells by causing them oxidative stress and does so in a targeted way. This stress targets mutations and more advanced cancers have many more mutations the extract can attack. This study was reported in the journal Cancer Letters and is available only to members and subscribers.