Science Daily (sciencedaily.com)
Monday, August 05, 2013
With some 300 million people around the world living with asthma, a study by Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) researchers that was released ahead-of- print found for the first time that maternal smoking can cause the third generation of offspring to suffer from the chronic lung disease.
The study, published online by the American Journal of Physiology — Lung Cellular and Molecular Physiology, reported that maternal nicotine exposure during pregnancy is linked to asthma in the third generation in disease models. This is known as a “transgenerational” linkage because the third generation was never directly exposed to nicotine or smoking. Previous research had found nicotine exposure was linked to asthma in the second generation, or was a “multigenerational” cause of asthma.
“Even though there are multiple causes for childhood asthma, research linking this serious chronic condition to maternal nicotine exposure during pregnancy for up to three generations should give mothers-to-be even more reasons to reconsider smoking,” said Virender K. Rehan, MD, an LA BioMed lead researcher and the corresponding author of the study. “Eliminating the use of tobacco during pregnancy could help halt the rise in childhood asthma and ensure healthier children for generations to come.”